Microbiota, gastrointestinal infections, low-grade inflammation, and antibiotic therapy in irritable bowel syndrome (IBS): an evidence-based review

نویسندگان

  • Max Schmulson
  • María Victoria Bielsa
  • Ramón Carmona-Sánchez
  • Angélica Hernández
  • Aurelio López-Colombo
  • Yolanda López Vidal
  • Mario Peláez-Luna
  • José María Remes-Troche
  • José Luis Tamayo
  • Miguel Angel Valdovinos
چکیده

a Laboratory of Liver, Pancreas, and Motility (HIPAM), Department of Experimental Medicine, Universidad Nacional Autónoma de México (UNAM) Hospital General de México, Mexico City, Mexico b Department of Gastroenterology, School of Medicine, Universidad Autónoma de Guadalajara, Guadalajara-Jal., Mexico c Gastroenterology Service, Internal Medicine Service, Hospital Ángeles-CMP, San Luis Potosí-S.L.P., Mexico d Endoscopy Service, Instituto Nacional de Cancerología. Mexico City, Mexico e Coordination of Health Research Delegation, Instituto Mexicano del Seguro Social, Puebla-Pue., Mexico f Molecular Microbial Immunology Program, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico g Laboratory of Digestive Physiology and Gastrointestinal Motility, Medical and Biological Research Institute, Universidad Veracruzana, Veracruz, Veracruz h School of Medicine, Miguel Alemán Valdés, Veracruz-Ver, Mexico i Health Sciences Research and Teaching Center, Universidad Autónoma de Sinaloa. Hospital Civil de Culiacán, Culiacán-Sin., Mexico j Department of Gastroenterology. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

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Microbiota, gastrointestinal infections, low-grade inflammation, and antibiotic therapy in irritable bowel syndrome: an evidence-based review.

BACKGROUND Post-infectious irritable bowel syndrome (PI-IBS) prevalence, small intestinal bacterial overgrowth (SIBO), altered microbiota, low-grade inflammation, and antibiotic therapy in IBS are all controversial issues. AIMS To conduct an evidence-based review of these factors. METHODS A review of the literature was carried out up to July 2012, with the inclusion of additional articles a...

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The gut-brain axis has been described as a bi-directional neuro-humeral communication system and is implicated in the pathogenesis of functional gastrointestinal disorders such as irritable bowel syndrome (IBS). Recent work has shown that a subset of patients with IBS show evidence of low grade immune activation and inflammation in the colonic mucosa. This review focuses on the role of the inte...

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Progress in the understanding of the pathophysiology of irritable bowel syndrome (IBS), once thought to be a purely psychosomatic disease, has advanced considerably and low-grade inflammation and changes in the gut microbiota now feature as potentially important. The human gut harbours a huge microbial ecosystem, which is equipped to perform a variety of functions such as digestion of food, met...

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تاریخ انتشار 2015